信号轉導調控和腫瘤轉移、複發實驗室
基本信息：
唐小龍，博士，2003网站太阳集团，教授/博士生導師
聯系方式：xltang@hnu.edu.cn
教育經曆：
2009/9–2014/12，華東師範大學生命醫學研究所、上海市調控生物學重點實驗室，理學博士
2005/9–2009/6，華東師範大學生物技術專業，理學學士
科研工作經曆：
2015/7–2018/6，武漢大學-深圳大學，博士後研究。
2018/7–2022/5， 深圳大學醫學部，副研究員。
2022/6-至今，2003网站太阳集团，教授。
研究方向：
近年來實驗室主要圍繞信号轉導調控在腫瘤轉移複發和衰老相關疾病中的作用開展研究。相關研究成果發表在Nature Communications （2017/2021），Cancer Research （2013），EMBO J （2020），Science Advances（2020），Nucleic Acids Research （2020），Oncogene（2018），Communications Biology （2021），Nature Metabolism （2019），Theranostics （2022），Journal of Investigative Dermatology （2022）等國際主流雜志。重要研究發現包括：揭示了G蛋白偶聯受體GPR116調控乳腺癌轉移及相關機制；系統地闡釋了去乙酰化酶SIRT7在乳腺癌轉移、耐藥、複發中的信号調控機制；發現了SIRT7在血管内皮、毛囊幹細胞等組織器官中的抗衰老作用。實驗室現開展的研究包括以下：
1. 信号轉導調控和腫瘤轉移複發
1）G蛋白偶聯受體（GPCRs）調控腫瘤轉移複發的機制研究。
2）蛋白質翻譯後修飾影響腫瘤細胞休眠以及轉移複發的機制研究。
2. 血管穩态和相關疾病：受體信号轉導和血管穩态及機體代謝的調節。
實驗室熱忱期待各位同學和同仁的加入，共同發展！歡迎本科生同學加入實驗室實習、體驗！
聯系方式：xltang@hnu.edu.cn
科研項目/個人榮譽：
1. 2003网站太阳集团高層次人才啟動基金，2022-2025.
2. 深圳市國内高層次人才，2018-2023。
3. 國家自然科學基金重大項目，DNA同源重組及DNA雙鍊斷裂修複的分子機制研究，32090033，2021-2025，研究骨幹。
4. 深圳市基礎研究重點項目，中藥化合物組合抗腫瘤研究，2021N063，2022-2024，研究骨幹。
5. 國家自然科學基金面上項目，SIRT7的乙酰葡萄糖胺修飾在肝癌中的功能和機制研究，2020/01–2023/12，81972602，主持。
6. 國家自然科學基金青年基金，SMAD4-SIRT7信号軸調控結直腸癌發展及轉移的機制研究，2018/01–2020/12，81702909，主持。
7. 中國博士後科學基金面上項目，SIRT7調控乳腺癌轉移的機制研究，2015M582419，2015/10–2017/10，主持。
研究成果（* Corresponding authors，# Co-first authors）：
1. Guo Li, Xiaolong Tang*, Shuping Zhang, Ben Wang, Zhili Deng, Hongfu Xie, Baohua Liu, Ji Li*. (2022). Aging-conferred SIRT7 Decline Inhibits Rosacea-like Skin Inflammation via Modulating TLR2-NF-κB Signaling. Journal of Investigative Dermatology, 2022 Apr 10; S0022-202X (22)00273-1. (IF: 8.6).
2. Yalan Wu, Xiaolong Tang, Sharen Lee, Huiling Hong, Xiaoyun Cao, Chi Wai Lau, Baohua Liu, Ajay Chawla, Ronald Ching Wan Ma, Yu Huang, Kathy O Lui, Xiao Yu Tian*. (2022). Endothelial PPARdelta facilitates the post-ischemic vascular repair through interaction with HIF1alpha. Theranostics, 12(4):1855-1869. (IF: 11.5).
3. Xiaolong Tang, Guo Li, Lei Shi, Fengting Su, Minxian Qian, Zuojun Liu, Yuan Meng, Shimin Sun, Ji Li, Baohua Liu*. (2021). Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis. Nature Communications, 2021 Aug 25;12(1):5058. (焦點論文) (IF: 14.92).
4. Xiaolong Tang#*, Lizhi Cheng#, Guo Li#, Yong-Ming Yan, Fengting Su, Dan-Ling Huang, Shuping Zhang, Zuojun Liu, Minxian Qian, Ji Li, Yong-Xian Cheng*, Baohua Liu*. (2021). Novel small-molecule compound D6 overcomes EGFR-T790M-mediated resistance in non-small cell lung cancer. Communications Biology, 2021 Dec 13; 4(1):1391. (IF: 6.24)
5. Fengting Su#, Xiaolong Tang#*, Guo Li, Andreas Koeberle, Baohua Liu*. (2021). SIRT7–SREBP1 restrains cancer cell metabolic reprogramming by upregulating IDH1. Genome Instability & Disease, (2021) 2:126–137.
6. Guo Li#, Xiaolong Tang#, Shuping Zhang, Meiling Jin, Ming Wang, Zhili Deng, Zuojun Liu, Minxian Qian, Wei Shi, Zimei Wang, Hongfu Xie, Ji Li*, Baohua Liu*. (2020). SIRT7 evokes quiescent hair follicle stem cells and ensures hair growth in mice. EMBO J, 2020 Sep 15;39(18):e104365. (IF: 11.6).
7. Xiaolong Tang, Guo Li, Fengting Su, Yanling Cai, Lei Shi, Yuan Meng, ZuoJun Liu, Jie Sun, Ming Wang, Minxian Qian, Zimei Wang, Xingzhi Xu, Yong-Xian Cheng, Wei-Guo Zhu, Baohua Liu*. (2020). HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration. Nucleic Acids Research, 2020 Apr 6; 48(6):2912-2923.(IF: 16.97).
8. Shimin Sun#, Weifeng Qin#, Xiaolong Tang#, Yuan Meng, Wenjing Hu, Shuju Zhang, Minxian Qian, Zuojun Liu, Xinyue Cao, Qiuxiang Pang, Bosheng Zhao, Zimei Wang, Zhongjun Zhou, Baohua Liu*. (2020).Vascular endothelium–targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model. Science Advances, 2020 Feb 19;6(8):eaay5556. (IF: 14.14).
9. Zuojun Liu#, Minxian Qian#, Xiaolong Tang, Wenjing Hu, Shimin Sun, Guo Li, Shuju Zhang, Fanbiao Meng, Xinyue Cao, Jie Sun, Cheng Xu, Bing Tan, Qiuxiang Pang, Bosheng Zhao, Zimei Wang, Youfei Guan, Xiongzhong Ruan, Baohua Liu*. (2019). SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis. Nature Metabolism，2019, 1, pages1141–1156. (IF: 13.7).
10. Lei Shi#, Xiaolong Tang#, Minxian Qian, Zuojun Liu, Fanbiao Meng, Li Fu, Zimei Wang, Wei-Guo Zhu, Jian-Dong Huang, Zhongjun Zhou, Baohua Liu*. (2018). A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. Oncogene, 2018 Dec;37(49):6299-6315. (IF: 9.87).
11. Xiaolong Tang#, Lei Shi#, Ni Xie#, Zuojun Liu, Minxian Qian, Fanbiao Meng, Qingyang Xu, Minyan Zhou, Xinyue Cao, Wei-Guo Zhu, Baohua Liu*. (2017). SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis, Nature Communications, 2017 Aug 22; 8(1):318. (IF: 14.92).
12. Xiaolong Tang#, Rongrong Jin#, Guojun Qu, Xiu Wang, Zhenxi Li, Zengjin Yuan, Chen Zhao, Stefan Siwko, Tieliu Shi, Ping Wang, Jianru Xiao, Mingyao Liu, Jian Luo*. (2013). GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Galphaq-p63RhoGEF-Rho GTPase pathway. Cancer Research, 2013, 73(20):6206-6218. (IF: 12.7).
13. Xiaolong Tang, Ying Wang, Dali Li, Jian Luo*, Mingyao Liu*. (2012). Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets, Acta Pharmacologica Sinica, 2012, 33(3):363-371. (IF: 6.15).
14. Qian, M., Liu, Z., Peng, L., Tang, X., Meng, F., Ao, Y., Zhou, M., Wang, M., Cao, X., Qin, B., et al. (2018). Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. Elife.
15. Tao Zheng, Li-Zhi Cheng, Yong-Ming Yan, Fu-Rong Xu, Xiao-Long Tang, Xiao-Zhen Li, Fu-Ying Qin, Bao-Hua Liu, Yong-Xian Cheng. (2018). Compounds from the Roots of Codonopsis pilosula and Their SIRT1 Regulatory Activity. Natural Product Communications, volume: 13 issue: 1.
16. Ming Wang, Lulu Wang, Minxian Qian, Xiaolong Tang, Zuojun Liu, Yiwei Lai, Ying Ao, Yinghua Huang, Yuan Meng, Lei Shi, Linyuan Peng, Xinyue Cao, Zimei Wang, Baoming Qin, Baohua Liu*. PML2-mediated thread-like nuclear bodies mark deep senescence in Hutchinson-Gilford progeria syndrome. Aging Cell, 2020.
17. Linyuan Peng, Minxian Qian, Zuojun Liu, Xiaolong Tang, Yue Jiang, Shimin Sun, Xinyue Cao, Qiuxiang Pang, Baohua Liu*. eacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis. Nucleic Acids Research, 2020.
18. Meng, F., Qian, M., Peng, B., Peng, L., Wang, X., Zheng, K., Liu, Z., Tang, X., Zhang, S., Sun, S., Cao, X., Pang, Q., Zhao, B., Ma, W., Songyang, Z., Xu, B., Zhu, W. G., Xu, X., & Liu, B*. (2020). Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice. eLife, 9, e55828.
19. Jian Luo, Xiaolong Tang and Anliang Dong, Induction of cancer cell senescence: Role of caffeic acid 3, 4-dihydroxy-phenethyl ester, Springer Press, Volume 3, 2014.
