基本情況
2003网站太阳集团，2003网站太阳集团，教授/博士生導師，先後主持國家自然科學基金青年項目、面上項目、海外合作項目多項。E-mail: huangjing16@hnu.edu.cn
教育經曆
2005-2010 武漢大學，化學生物學，博士
2001-2005 湖南農業大學，應用化學專業，本科
工作經曆
2021至今 2003网站太阳集团
2017年至今 化學生物傳感與計量國家重點實驗室
2016年-至今 2003网站太阳集团生物學院，化學生物學與納米醫學研究所
2010-2015 美國國立衛生研究院（NIH），博士後
研究領域
黃靜教授課題組的研究領域主要是通過化學工具和手段，對生物大分子進行修飾、調控；研究DNA從識别到修飾、從損傷到修複的過程。從分子水平研究細胞衰老、死亡的機理，為相關疾病靶向治療提供理論基礎和新思路。研究方向涉及化學生物學，細胞生物學，藥學、基礎醫學等多學科的交叉。具體研究方向包括：
1、DNA損傷修複機理與基因組的穩定性
2、生物大分子的化學調控
3、靶向藥物的設計及其作用機理研究
誠摯歡迎化學、生命科學、基礎醫學以及相關交叉學科背景的優秀碩/博生加入，熱烈歡迎博士後、助理教授、副教授等加盟合作。
科研項目
1. 國家自然科學基金青年項目，21708007，DNA轉位酶FANCM抑制劑的篩選及其在DNA交聯損傷修複通路中的作用研究，2018.01-2020.12，主持。
2. 國家自然科學基金面上項目，31871365，基于DNA纖維熒光原位雜交技術的DNA交聯損傷修複研究，2019.01-2022.12，主持。
3. 國家自然科學基金海外合作項目，21828701，泛素化組蛋白H4探針的設計合成以及在基因損傷修複中的應用，2019.01-2020.12
4. 黃靜，湖南省自然科學基金青年項目，2018JJ3030，基于活性氧激活的RNA G-四鍊體探針的設計、合成及其生物活性研究，2018.01-2020.12，主持。
代表論文
1. Guorui Li#, Yi Yang #, Yaya Zhang, Peiling Huang, Jiangyu Yan, Zhibin Song, Quan Yuan，Jing Huang*，A Reactive Oxygen Species-Tyrosinase Cascade Activated Prodrug for Selectively Suppressing Melanoma，CCS Chemistry， 2021, 3, 1622–1638.
2. Song Liu, Lingli Bu, Yuming Zhang, Jiangyu Yan, Ling Li, Guorui Li *, Zhibin Song *, Jing Huang *, Subtle Structural Changes of Dyes Lead to Distinctly Different Fluorescent Behaviors in Cellular Context: The Role of G-Quadruplex DNA Interaction Using Coumarin-Quinazolinone Conjugates as a Case Study, Analytical Chemistry, 2021, 93, 12, 5267-5276.
3. Jing Huang*, Jing Zhang, Marina A. Bellani, Durga Pokharel, Julia Gichimu, Ryan C. James, Himabindu Gali, Chen Ling, Zhijiang Yan, Dongyi Xu, Junjie Chen, Amom Ruhikanta Meetei, Lei Li, Weidong Wang, Michael M. Seidman*, Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2, Cell Reports, 2019, 27(6), 1794-1808.
4. Florian Rohleder#, Jing Huang#, Yutong Xue, Jochen Kuper, Adam Round, Michael Seidman*, Weidong Wang*, and Caroline Kisker*, FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks, Nucleic Acids Research, 2016, 44, 3219–3232.
5. Jing Huang, Shuo Liu, Marina A. Bellani, Arun Kalliat Thazhathveetil, Chen Ling, Johan P. de Winter, Yinsheng Wang, Weidong Wang, and Michael M. Seidman*, “The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks”, Molecular Cell. 2013, 52, 434–446.
6. Xiaolin Wang#, Jing Huang#, Yangyang Zhou, Shengyong Yan, Xiaocheng Weng, Xiaojun Wu, Minggang Deng, Xiang Zhou*，Conformational Switching of G-Quadruplex DNA by Photoregulation，Angewandte Chemie International Edition, 2010 , 49, 5305-539.
其他論文
1. Song Liu, Han Su, Lingli Bu, Jiangyu Yan, Guorui Li , Jing Huang*, Fluorogenic Probes for Mitochondria and Lysosomes via Intramolecular Photoclick Reaction Analyst, 2021, 146, 1369-1375.
2. Tao Luo, Lingli Bu, Siyu Peng, Yaya Zhang, Zhi Zhou, Guorui Li*, Jing Huang*, One-step microwave-assisted preparation of oxygen-rich multifunctional carbon quantum dots and their application for Cu2+-curcumin detection, Talanta, 2019, 205, 120117-120125.
3. Jihuan Yang, Yaya Zhang, Xuejiao Bai, Guorui Li*, Zhiming Xing, Cheng Zhong, Jia Zhou, Song Liu, Zhibin Song*, Jing Huang*, Coumarin-Quinazolinone conjugate with large two photon action cross-section assisted by intramolecular hydrogen bond for bioimaging, Sensors & Actuators: B. Chemical, 2019, 297, 126720-126729.
4. Lingli Bu, Tao Luo, Huanjun Peng, Ling Li, Dengying Long, Jingdong Peng*, Jing Huang*, One-step synthesis of N-doped carbon dots, and their applications in curcumin sensing, fluorescent inks, and super-resolution nanoscopy, Microchimica Acta, 2019, 186, 675-686.
5. Lu Liu, Yaya Zhang, Jia Zhou, Jihuan Yang, Cheng Zhong, Yueshou Zhang, Yu Luo, Yang Fua, Jing Huang*, Zhibin Song*, Yiyuan Peng, Design of a quinazolinone-based environment-sensitive fluorescent dye: Solvatochromic fluorescence and application for one-photon and two-photon bioimaging, Dyes and Pigments, 2019, 165, 58-64.
6. Jing Huang, Himabindu Gali, Julia Gichimu, Marina A. Bellani, Durga Pokharel, Manikandan Paramasivam, Michael M. Seidman*, Single Molecule Analysis of Laser Localized Psoralen Adducts, Jounal of Visualized Experiments, 2017，122, 55541-55547.
7. Jing Huang, Himabindu Gali, Manikandan Paramasivam, Parameswary Muniandy, Julia Gichimu, Marina A. Bellani and Michael M. Seidman*, Single molecule analysis of laser localized interstrand crosslinks. Frontiers in Genetics, 2016, 7, 84-93.
8. Chen Ling, Jing Huang, Zhijiang Yan, Yongjiang Li, Mioko Ohzeki, Masamichi Ishiai, Dongyi Xu, Minoru Takata, Michael Seidman*, and Weidong Wang*, Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks, Cell Discovery, 2016, 2, 16047.
9. Minghui Bai, Jing Huang, Xiaolong Zheng, Zhibin Song, Miru Tang, Wuxiang Mao, Libo Yuan, Jun Wu, Xiaocheng Weng, Xiang Zhou *, Highly Selective Suppression of Melanoma Cells by Inducible DNA Cross-Linking Agents: Bis(catechol) Derivatives, Journal of the American Chemical Society, 2010, 132, 15321-15327.
10. Jing Huang, Ming Wang, Yangyang Zhou; Xiaocheng Weng, Liang Shuai, Xiang Zhou *, Deqing Zhang, Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission, Bioorganic & Medicinal Chemistry, 2009, 17(22), 7743-7748.
11. Jing Huang#, Guorui Li#, Zhiguo Wu, Zhibin Song, Yangyang Zhou, Liang Shuai, Xiaocheng Weng, Xiang Zhou *, Guangfu Yang, Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomere G-quadruplex, Chemical Communications, 2009, 8, 902-904.
12. Guorui Li#, Jing Huang#, Ming Zhang, Yangyang Zhou, Dan Zhang, Zhiguo Wu, Shaoru Wang, Xiaocheng Weng, Xiang Zhou *, Guangfu Yang, Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand, Chemical Communications, 2008, 38,4564-4566.
13. Boqiao Fu#, Jing Huang#, Lige Ren, Xiaocheng Weng, Yangyang Zhou, Yuhao Du， Xiaojun Wu, Xiang Zhou *, Guangfu Yang, Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands, Chemical Communications, 2007, 31, 3264-3266.
14. An-Ming Zhang#, Jing Huang#, XiaoCheng Weng, JinXi Li, Lige Ren, ZhiBin Song, XiaoQin Xiong, Xiang Zhou *, XiaoPing Cao, Yan Zhou, A water-soluble, octacationic zinc phthalocyanine as molecular probe for nucleic acid secondary structure, Chemistry & Biodiversity, 2007, 4(2), 215-223.
獎勵與榮譽
2014美國國立衛生研究院（NIH）優秀博士後研究員獎
2013美國國立衛生研究院（NIH）優秀博士後研究員獎
